Methyl 2-chloro-5-fluorobenzoate synthesis
- Product Name:Methyl 2-chloro-5-fluorobenzoate
- CAS Number:647020-63-1
- Molecular formula:C8H6ClFO2
- Molecular Weight:188.58
67-56-1
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2252-50-8
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647020-63-1
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$30.00/1g
Yield:-
Reaction Conditions:
with sulfuric acid for 24 h;Reflux;
Steps:
4.A
To a solution of 2-chloro-5-fluorobenzoic acid (22) (35.0 g, 200 mmol) in methanol (350 mL) was added cone. H2SO4 (5 mL). The mixture was heated at reflux for 24 h. Most of the solvent was evaporated, and the resulting mixture was diluted with water (300 mL). The mixture was extracted with EtOAc (150 mL×2). The combined extracts were washed with saturated NaHCO3 and brine, dried over MgSO4, and concentrated to give methyl 2-chloro-5-fluorobenzoate (23).
References:
Wang, Weibo;Li, Tongshuang US2011/160212, 2011, A1 Location in patent:Page/Page column 22; 23