Methyl 2-chloro-3-quinolinecarboxylate synthesis
- Product Name:Methyl 2-chloro-3-quinolinecarboxylate
- CAS Number:16498-85-4
- Molecular formula:C11H8ClNO2
- Molecular Weight:221.64
67-56-1
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16498-85-4
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Yield: 80%
Reaction Conditions:
with sulfuric acid at 60; for 2 h;
Steps:
434.a Example 434 step a:
A solution of the compound 2-chloroquinoline-3-carboxylic acid (414 mg, 2 mmol) in MeOH(20 mL) and H2S04 (1 mL) was stirred for 2 hours at 60 °C. It was quenched by H20 (30 mL)at 0 °C and adjusted pH to 89, extracted with EA (3x), dried Na2SO4, filtered to give desiredcompound as a yellow solid (354 mg, 80 %). ESI MS m/z = 222.2 [M+Hjt
References:
ENANTA PHARMACEUTICALS, INC.;SHOOK, Brian, C.;KIM, In, Jong;BLAISDELL, Thomas, P.;YU, Jianming;PANARESE, Joseph;OR, Yat, Sun WO2017/15449, 2017, A1 Location in patent:Page/Page column 325
67-56-1
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73568-25-9
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16498-85-4
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62-53-3
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16498-85-4
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103-84-4
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16498-85-4
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91301-03-0
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16498-85-4
50 suppliers
$25.00/100mg