ChemicalBook CAS DataBase List METHYL 2-(4-(METHYLSULFONYL)PHENYL)ACETATE

METHYL 2-(4-(METHYLSULFONYL)PHENYL)ACETATE synthesis

7synthesis methods

Product Name:METHYL 2-(4-(METHYLSULFONYL)PHENYL)ACETATE
CAS Number:300355-18-4
Molecular formula:C10H12O4S
Molecular Weight:228.26

67-56-1 Synthesis

67-56-1
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32703-82-5 Synthesis

6-tert-Butyl-2,3-naphthalenedicarbonitrile

32703-82-5
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METHYL 2-(4-(METHYLSULFONYL)PHENYL)ACETATE

300355-18-4
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Yield:300355-18-4 100%

Reaction Conditions:

with sulfuric acid for 16 h;Heating / reflux;

Steps:

1

Methyl 4-(methanesulfonyl)phenyl acetate: A solution of 4-(methanesulfonyl)phenyl acetic acid (21.8 g, 101 mmol), methanol (250 mL), and concentrated sulfuric acid (1 mL) was heated under reflux for 16 h. The reaction mixture was allowed to cool to 25° C. and evaporated to dryness in vacuo. The residue was taken up in 10% aqueous sodium bicarbonate (200 mL) and ethyl acetate (200 mL). The isolated water phase was extracted with further ethyl acetate (2×200 mL), and the combined organic phases were washed with water (100 mL), dried with anhydrous sodium sulphate, and evaporated to dryness in vacuo to give methyl 4-(methanesulfonyl)phenyl acetate. Yield: 24.0 g (100%). ¹H-NMR (CDCl₃, δ ppm): 7.91 (d, 2H); 7.50 (d, 2H); 3.74 (s, 2H); 3.73 (s, 3H); 3.05 (s, 3H).

References:

US2008/139562,2008,A1 Location in patent:Page/Page column 14

70290-37-8 Synthesis