Methyl 2,3,4-tri-O-benzyl-alpha-D-glucopyranoside synthesis
- Product Name:Methyl 2,3,4-tri-O-benzyl-alpha-D-glucopyranoside
- CAS Number:53008-65-4
- Molecular formula:C28H32O6
- Molecular Weight:464.55
1223405-93-3
0 suppliers
inquiry
53008-65-4
113 suppliers
$39.20/250MG
Yield:53008-65-4 84%
Reaction Conditions:
with ammonium chloride;zinc in tetrahydrofuran;methanol at 20; for 1 h;chemoselective reaction;Reagent/catalyst;Solvent;
Steps:
Deprotection of (2-nitrophenyl)acetate
Zn (26 mg, 0.398 mmol) and NH4Cl (12.8mg 0.24mmol) were added to the solution of methyl 2,3,4-tri-O-benzyl-6-O-(2-nitrophenyl)acetyl-α-D-glucopyranoside (50 mg, 0.079 mmol) in the mixture of THF (1.6 mL) and MeOH (0.4mL). The mixture was stirred for 1 h at rt. The mixture was diluted with CH2Cl2 (20 mL) and washed with 1 N aq. HCl, (10 mL) and with water (2 × 10 mL) the organic phase was dried(MgSO4), filtrated and concentrated. The product (A) was isolated after columnchromatography (hexane-EtOAc; 2:1) of the crude residue as a white solid (31 mg, 84 %)
References:
ágoston, Károly;ágoston, ágnes;Dorgan, Colin R.;Fügedi, Péter [Carbohydrate Research,2015,vol. 418,p. 98 - 103] Location in patent:supporting information
250127-77-6
0 suppliers
inquiry
53008-65-4
113 suppliers
$39.20/250MG
88154-14-7
0 suppliers
inquiry
53008-65-4
113 suppliers
$39.20/250MG
100-39-0
432 suppliers
$10.00/10g
97-30-3
362 suppliers
$17.00/25g
53008-65-4
113 suppliers
$39.20/250MG
82231-38-7
0 suppliers
inquiry
53008-65-4
113 suppliers
$39.20/250MG