Yield:130-37-0 78%

Reaction Conditions:

with sodium hydrogensulfite in ethanol;water at 75;Temperature;

Steps:

11
At 75 °C β-menadione ethanol solution, In the tank 1, the mass fraction of β-menadione was 18% A pre-prepared 75% aqueous solution of 35% sodium bisulfite was added to the tank 2, The β-menadione solution and sodium bisulfite solution preheated to 75 °C were continuously pumped into the static mixer 5 at a volume flow ratio of 3.1:1, The molar ratio of β-menadione and sodium bisulfite was 1:0.7, The mixed material enters the tubular reactor 6, controls the temperature of the reaction liquid to be 75 °C, The reaction residence time was 5 minutes. The reactor outlet material is cooled by the cooler 7 into the crystallization kettle 8, frozen to 0 °C, Insulation crystallization 2 hours, centrifugal separation, Cold ethanol washing crystallization, Wet product drying, We were menadione sodium bisulfite yield of 78%.

References:

Zhejiang rongyao chemical co. ltd;Shi, xiangjun;Zhuang, yuguo;Chen, RenEr CN104163779, 2016, B Location in patent:Paragraph 0041; 0042

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