ChemicalBook CAS DataBase List Medetomidine Impurity 2

Medetomidine Impurity 2 synthesis

6synthesis methods

Product Name:Medetomidine Impurity 2
CAS Number:33967-19-0
Molecular formula:C10H14O
Molecular Weight:150.22

3637-01-2
134 suppliers
$11.00/1g

33967-19-0
39 suppliers
$120.00/100mg

Yield:33967-19-0 88.2%

Reaction Conditions:

with root of parsley (Petroselinum crispum (Mill_.) Fuss) in water at 20; pH=7; for 72 h;Green chemistry;Enzymatic reaction;Reagent/catalyst;

Steps:

4.4. General procedure for the asymmetric reduction of 1-(3,4-dimethylphenyl)ethanone by different plant roots

General procedure: The plant roots were washed with distilled water and then maintained in a 5% sodium hypochlorite aqueous solution for 20 min, after which they were washed with ethanol, manipulated under a sterile laminar flow cabinet, peeled with a sterilised knife and then cut into small thin slices (approx. 5 mm x 5 mm x 2 mm). In an Erlenmeyer flask (1 L), 100 g of plants cut into pieces and 200 mL of distilled water were added and left on a shaker for 15 min. The substrate 1-(3,4-dimethylphenyl)ethanone (3.4 mmol) was then added dropwise and the mixture was stirred at room temperature for 3 days at 130 rpm. The reaction mixture was filtered through pleated filter paper, tissue pieces were washed with ethyl acetate and extraction of product 1-(3,4-dimethylphenyl)ethanol with ethyl acetate was carried out from the filtrate (3 x 100 mL). The ethyl acetate extract was dried over Na2SO4, filtered over a pleated paper filter and evaporated in vacuum using a rotary vacuum evaporator. The resulting viscous liquid was purified on a silica gel column and eluted using hexane:ethyl acetate (4:1, v/v) to afford the product and the yield was calculated using the conventional formula of weighing the initial and final product.

References:

Pavokovi?, Dubravko;Bu?a, Renata;Andra?ec, Fran;Roje, Marin;Bubalo, Marina Cvjetko;Redovnikovi?, Ivana Radoj?i? [Tetrahedron Asymmetry,2017,vol. 28,# 5,p. 730 - 733]

67-63-0 Synthesis