ChemicalBook CAS DataBase List Lysergic acid diethylamide

Lysergic acid diethylamide synthesis

8synthesis methods

Product Name:Lysergic acid diethylamide
CAS Number:50-37-3
Molecular formula:C20H25N3O
Molecular Weight:323.44

67-56-1 Synthesis

67-56-1
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7732-18-5
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$12.69/100ml

109-89-7
460 suppliers
$10.00/5g

530-62-1 Synthesis

530-62-1
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$6.00/25g

82-58-6 Synthesis

9,10-DIDEHYDRO-6-METHYL-ERGOLINE-8-CARBOXYLIC ACID

82-58-6
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50-37-3
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$27.89/005-1ml

Yield:50-37-3 3.65 g (75.7%)

Reaction Conditions:

in dichloromethane;N,N-dimethyl-formamide

Steps:

1 Synthesis of D-lysergic acid diethyl amide 1
Example 1 Synthesis of D-lysergic acid diethyl amide 1 A mixture of 4.0 g (0.015 mol) of D-lysergic acid and 200 mL of dry DMF, under argon, was treated with 3.6 g (0.022 mol) of carbonyl diimidazole and stirred at room temperature for 1 hour. The reaction was treated with 15.2 mL (0.15 mol) of diethylamine and stirred at room temperature overnight. The reaction was concentrated at reduced pressure. The residue was taken up in 250 mL of CH₂ Cl₂ and washed with 250 mL of H₂ O. Insoluble material was removed by filtration and the layers were separated. The organic portion was washed with 250 mL of saturated brine solution, dried over anhydrous Na₂ SO₄ and concentrated at reduced pressure. The residue was chromatographed on 500 g of silica gel using 3% CH₃ OH in CH₂ Cl₂ as eluent to yield 3.65 g (75.7%) of D-LSD [α]_D =+50.4° (c=1%; CHCl₃) as a light brown amorphous solid. The 8α-epimer (also known as iso-LSD) has [α]_D =+226° (c=1%; CHCl₃).