ChemicalBook CAS DataBase List Lincomycin

Lincomycin synthesis

2synthesis methods

Product Name:Lincomycin
CAS Number:154-21-2
Molecular formula:C18H34N2O6S
Molecular Weight:406.54

Lincomycin, 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidincarboxamido)-1-methylthio-D-erythro-α-D-galacto-octopyranoside (32.5.1), is the first lincosamide that has found use in clinical practice, and which was isolated in 1962 from the culture liquid of the activity of the actinomycete Streptomyces lincolnensis.

859-18-7
510 suppliers
$6.00/100mg

154-21-2
201 suppliers
$105.00/5mg

Yield:-

Steps:

Multi-step reaction with 4 steps
1: pyridine / 8 h / 2 - 20 °C
2: acetic acid / methanol / 18 h / 30 °C
3: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 h / 30 °C
4: potassium carbonate / methanol / 20 h / 130 °C

References:

Tianjin Kelun Pharmaceutical Co., Ltd.;Li Faguang;Wang Qianqian;Huang Chang;Wang Yufen;Wang Linlin;Huo Xianghong;Wang Qi;Wang Lichun;Wang Jingyi CN110606865, 2019, A

FullText

25420-97-7 Synthesis

Methyl 6,8-Dideoxy-6-[[[(2S,4R)-1-Methyl-4-propyl-2-pyrrolidinyl]carbonyl]aMino]-1-thio-2,3,4-tris-O-(triMethylsilyl)-D-erythro-α-D-galacto-octopyranoside

25420-97-7
10 suppliers
$496.00/50mg

154-21-2
201 suppliers
$105.00/5mg

References

Lincomycin Related Search:

Propyl gallate Methyl salicylate 2-Thiobarbituric acid Isopropyl alcohol N-Methyl-2-pyrrolidone Propyl butyrate Thioacetamide Clindamycin phosphate Lincomycin 2,7-diacetate

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Lincomycin synthesis

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