ChemicalBook CAS DataBase List LEUCOMALACHITE GREEN

LEUCOMALACHITE GREEN synthesis

9synthesis methods

Product Name:LEUCOMALACHITE GREEN
CAS Number:129-73-7
Molecular formula:C23H26N2
Molecular Weight:330.47

100-52-7 Synthesis

100-52-7
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$17.30/2g

121-69-7 Synthesis

121-69-7
536 suppliers
$10.00/25mL

129-73-7
161 suppliers
$15.50/2g

Yield:129-73-7 85%

Reaction Conditions:

with N,N-dimethylformamidium hydrogen sulfate in neat (no solvent) at 120; for 4 h;Catalytic behavior;Reagent/catalyst;Temperature;

Steps:

General procedure for the synthesis of 3a-3i and 6j-6l
General procedure: To a mixture of aromatic aldehyde (2.0 mmol) and N,N-dimethylaniline or indole (5.0 mmol), ionic liquid AIL (0.2 mmol) was added, and the mixture was heated on an oil bath at 120 C with good stirring. After the completion of the reaction, monitored by thin-layer chromatography (TLC), the mixture was diluted with 5 cm3 ethyl acetate and 1 cm3 water. The organic layer was separated, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was recrystallized with ethanol and afforded the corresponding TRAMs 3a-3h and 6j-6l in good isolated yields. Or the residue was purified by silica gel column chromatography (200-400 mesh silica gel, 1:8 petroleum ether/ethyl acetate) to afford 3i. The aqueous layer containing the AIL was subjected to rotary evaporation at 60 C under reduced pressure to afford the recovered AIL. Also, the catalyst could be reused easily six times without apparent loss of activity in terms of yield (85-83%; Fig. 3).

References:

Kang, Li Q.;Gao, Han;Cai, Yue Q. [Monatshefte fur Chemie,2018,vol. 149,# 1,p. 57 - 62]

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