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ChemicalBook CAS DataBase List Jasmone
488-10-8

Jasmone synthesis

7synthesis methods
A review and classification on the synthesis of jasmone is available.
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: triethylamine / CH2Cl2 / 1.) 0 deg C , 30 min, 2.) room temperature, 2 h
2: 80 percent / NaI / tetrahydrofuran / 10 h
3: 1.10 g / tetrabutyl ammonium bromide, aq. NaOH / CH2Cl2 / 1.) 0 deg C, 3 h, 2.) room temperature, 6 h
4: 1.) NaH / 1.) ether, -5-0 deg C, 10 min, 2.) ether, 10-15 deg C, 3 h
5: conc. HCl / CH2Cl2; diethyl ether / 0.25 h / 20 °C
6: 85 percent / 0.5N NaOH / ethanol / 6.5 h / Heating

References:

Rao, A.V. Rama;Deshpande, V.H.;Reddy, S. Pulla [Synthetic Communications,1984,vol. 14,# 5,p. 469 - 476]

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