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ChemicalBook CAS DataBase List Isovaleric acid
503-74-2

Isovaleric acid synthesis

11synthesis methods
By oxidation of isoamyl alcohol or isovaleric aldehyde
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Yield:503-74-2 99.1%

Reaction Conditions:

with potassium acetate;palladium diacetate;C34H36O8 at 30 - 35; for 6 h;Catalytic behavior;Inert atmosphere;Reagent/catalyst;

Steps:

7-12 Example 7

General procedure: To a dry 1L three-neck flask, add isovaleraldehyde (160g, 1.86mol), isovaleric acid (160g, 1.57mol), the above ligand L2 (24.8mg, 0.04mmol), palladium acetate (44.9mg, 0.2mmol) ) And potassium acetate 260mg; mechanically stirred under a nitrogen atmosphere, after the temperature rises to 30°C, start to pass in air at a flow rate of 19.8g/h, and keep the reaction temperature between 3035°C by adding cooling water to the water bath Reaction in any range, after 8h reaction, isovaleric acid is prepared.

References:

CN110776412,2020,A Location in patent:Paragraph 0087-0111

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