Isophytol synthesis
- Product Name:Isophytol
- CAS Number:505-32-8
- Molecular formula:C20H40O
- Molecular Weight:296.53
2) by hydrogenation of Geranyl linalool (see monograph).
502-69-2
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$110.00/10mg
3536-96-7
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$56.60/100ml
505-32-8
209 suppliers
$29.12/5G
Yield:505-32-8 85%
Reaction Conditions:
in tert-butyl methyl ether at 0 - 5; for 2 h;
Steps:
8 Example 8 Isophytol
Add 200ml of anhydrous methyl tert-butyl ether and 90g (0.335mol) of plant ketone to a reaction flask equipped with a thermometer, stirring, and drying reflux tube. The temperature is reduced to 0°C, and 250ml of vinyl chloride Grignard solution is slowly added dropwise. (Containing vinyl chloride Grignard agent 0.369mol), after dripping the reaction below 5 for 2 hours, then dripping 100ml of saturated ammonium chloride solution to quench the reaction, add 200ml of water after filtration, stir, stand still for layering, use 200ml for the organic layer After washing with water, it was dried with anhydrous sodium sulfate, the solvent was recovered under reduced pressure, and the residue was subjected to rectification. The 2mmHg 125-135°C fraction was collected to obtain a pale yellow liquid, which is isophytol (84.4g, yield 85percent)
References:
Shanghai Modern Hasen (Business Qiu) Pharmaceutical Co., Ltd.;Henan Food Medicine Shenping Chayan Center;Wang Yingli;Zhang Pei;Jin Jianwen;Chen Hong;Wu Quan;Wei Wei;Guo Xuguang;Qin Fangqing;Wang Haixia;Liu Li CN111393275, 2020, A Location in patent:Paragraph 0061; 0098-0099
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505-32-8
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593-60-2
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502-69-2
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$110.00/10mg
505-32-8
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1117-52-8
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505-32-8
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$29.12/5G
3796-70-1
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505-32-8
209 suppliers
$29.12/5G