Imidazo[1,2-a]pyridine-7-carboxylic acid (9CI) synthesis
- Product Name:Imidazo[1,2-a]pyridine-7-carboxylic acid (9CI)
- CAS Number:648423-85-2
- Molecular formula:C8H6N2O2
- Molecular Weight:162.15
![Methyl imidazo[1,2-a]pyridine-7-carboxylate](/CAS/GIF/86718-01-6.gif)
86718-01-6
102 suppliers
$18.00/250mg
648423-85-2
103 suppliers
$48.00/250mg
Yield: 100%
Reaction Conditions:
with hydrogenchloride;water at 50; for 64 h;
Steps:
43
The title compound of Preparation 42 was dissolved in 100ml of HCI 37%. The reaction mixture was heated at 500C for 64h. After this time the mixture was concentrated to dryness and dried in the vacuum oven to give 1.95g of the title compound as a solid (yield=100%).LRMS: m/z 163 (M+1 )+ Retention time: 0.41 min (method A)1H NMR (200 MHz, DMSO-d6) ppm 7.79 (d, J=8Hz, 1 H), 8.31 (s, 1 H), 8.38(s,1 H), 8.48(s,1 H), 8.97(d,J=8Hz, 1 H) Yield 99.9%
References:
ALMIRALL, S.A.;GRIMA POVEDA, Pedro Manuel;AGUILAR IZQUIERDO, Nuria;MIR CEPEDA, Marta;LOPEZ MARTINEZ, Manuel WO2010/43377, 2010, A1 Location in patent:Page/Page column 54
874-39-5
84 suppliers
$30.00/250mg
648423-85-2
103 suppliers
$48.00/250mg