Huperzine A synthesis
- Product Name:Huperzine A
- CAS Number:120786-18-7
- Molecular formula:C15H18N2O
- Molecular Weight:242.32
![5,9-Methanocycloocta[b]pyridine-5(6H)-carboxylic acid, 11-ethylidene-9,10-dihydro-2-methoxy-7-methyl-, methyl ester, (11E)-](/CAS/20210305/GIF/120786-17-6.gif)
120786-17-6
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120786-18-7
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Yield:-
Steps:
Multi-step reaction with 5 steps
1: 20percent NaOH / tetrahydrofuran; methanol / 48 h / Heating
2: SOCl2 / toluene / 2 h / 80 °C
3: NaN3 / toluene / 8 h / 80 °C
4: Heating
5: 92 percent / Me3SiI / CHCl3 / 1) reflux, 8 h, 2) MeOH, reflux, overnight
References:
Kozikowski;Xia;Reddy;Tuckmantel;Hanin;Tang [Journal of Organic Chemistry,1991,vol. 56,# 15,p. 4636 - 4645]
![Carbamic acid, [(11E)-11-ethylidene-2,6,9,10-tetrahydro-7-methyl-2-oxo-5,9-methanocycloocta[b]pyridin-5(1H)-yl]-, methyl ester (9CI)](/CAS/20210305/GIF/134287-15-3.gif)
134287-15-3
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120786-18-7
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![5,9-Methanocycloocta[b]pyridine-5(6H)-carboxylic acid, 7,8,9,10-tetrahydro-8-hydroxy-2-methoxy-7-methyl-11-oxo-, methyl ester](/CAS/20210305/GIF/120686-01-3.gif)
120686-01-3
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120786-18-7
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$62.00/10mg
120686-09-1
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120786-18-7
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![Spiro[1,3-dioxolane-2,6'(5'H)-quinoline], 7',8'-dihydro-2'-methoxy-](/CAS/20200611/GIF/120685-99-6.gif)
120685-99-6
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120786-18-7
200 suppliers
$62.00/10mg