ChemicalBook CAS DataBase List H2N-PEG4-tBu

H2N-PEG4-tBu synthesis

4synthesis methods

Product Name:H2N-PEG4-tBu
CAS Number:581065-95-4
Molecular formula:C15H31NO6
Molecular Weight:321.41

581065-94-3
61 suppliers
$135.00/1G

581065-95-4
145 suppliers
$42.00/100mg

Yield:581065-95-4 50 g

Reaction Conditions:

with ammonium hydroxide;tetrabutylammomium bromide in dichloromethane at 40; for 24 h;

Steps:

1.3
The 150 g of the sulfonylated crude product obtained in step (2) was added to 200 ml of methylene chloride,Then add 100g ammonium hydroxide,10g tetrabutylammonium bromide,Warmed to 40 ,Stir for 24h.The reaction is over,Spin dry,Add 3M hydrochloric acid,Adjust PH = 3,With 300ml of dichloromethane,Extract 2 times,Then use sodium hydroxide solution to adjust PH = 9,Then extracted three times with 400ml of dichloromethane,Dried over anhydrous sodium sulfate,Spin dry,50 g of amino-terminated product was obtained.NMR data are as follows:

References:

Hunan Huateng Pharmaceutical Co., Ltd.;Deng Zeping;Li Hu;Cheng Jia CN107235848, 2017, A Location in patent:Paragraph 0021