ChemicalBook CAS DataBase List Fmoc-L-Serine

Fmoc-L-Serine synthesis

11synthesis methods

Product Name:Fmoc-L-Serine
CAS Number:73724-45-5
Molecular formula:C18H17NO5
Molecular Weight:327.33

56-45-1 Synthesis

56-45-1
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28920-43-6
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73724-45-5
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$5.00/1g

Yield:73724-45-5 88%

Reaction Conditions:

with sodium carbonate in 1,4-dioxane;water at 20; for 1 h;Cooling with ice;

Steps:

N-(9-Fluorenylmethoxycarbonyl)-L-serine (10)
To a solution of L-serine (3) (103 mg, 0.98 mmol) in aqueous10% sodium carbonate (3 mL) cooled on an ice bath was slowly added a solution of 9-fluorenylmethoxycarbonyl chloride (245 mg, 0.95 mmol) in 1,4-dioxane (3 mL). After stirring for 1 h at rt, themixture was washed with EtOAc to remove byproducts, added with 1M HCl, and extracted with EtOAc. Theorganic layer was washed with brine, dried over MgSO4, and evaporated to give 10 as a white solid (284 mg,88%). The spectral data of 10 were identical to the literature.33 The purity was confirmed by 1H NMR.

References:

Shimodaira, Shingo;Iwaoka, Michio [Arkivoc,2016,vol. 2017,# 2,p. 260 - 271]

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56-45-1 Synthesis

56-45-1
745 suppliers
$5.00/25g

82911-69-1 Synthesis