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ChemicalBook CAS DataBase List Ethyl tiglate
5837-78-5

Ethyl tiglate synthesis

7synthesis methods
By direct esterification of tiglic acid with ethyl alcohol in the presence of concentrated H2SO4 or by reaction of bromomethylethyl acetic acid ethyl ester with dimethylaniline.
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 1.) diisopropylamine, n-butyllithium / 1.) THF, hexane, -78 deg C, 30 min; 2.) -78 deg C, 15 min; room temp., 1 h
2: butyllithium / hexane; diethyl ether / -40 - -30 °C
3: triethylamine / methanol / 6 h / Heating

References:

Slougui, Nasser;Rousseau, Gerard;Conia, Jean-Marie [Synthesis,1982,# 1,p. 58 - 60]

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