ETHYL N-(2-CYANO-3-ETHOXYACRYLOYL)CARBAMATE synthesis
- Product Name:ETHYL N-(2-CYANO-3-ETHOXYACRYLOYL)CARBAMATE
- CAS Number:1187-34-4
- Molecular formula:C9H12N2O4
- Molecular Weight:212.2
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Yield:1187-34-4 87%
Reaction Conditions:
in acetonitrile at 80; for 4 h;Inert atmosphere;
Steps:
12.4; 27.3 Step 4: Example 12g
To a solution of Example 12f (936 mg, 6 mmol) in acetonitrile (6 mL) was added triethyl orthoformate (2.7 g, 18 mmol) under nitrogen. The mixture was heated to 80°C for 4 h. The reaction mixture was cooled and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel, Petroleum Ether/EtOAc = 10/1) to afford Example 12g (1.1 g, yield 87%) as a yellow solid. LCMS [M+l]+ = 213.2
References:
WO2019/240938,2019,A1 Location in patent:Paragraph 00314; 00379
