ETHYL IMIDAZOLE-2-CARBOXYLATE synthesis
- Product Name:ETHYL IMIDAZOLE-2-CARBOXYLATE
- CAS Number:33543-78-1
- Molecular formula:C6H8N2O2
- Molecular Weight:140.14
288-32-4
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124-38-9
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75-03-6
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33543-78-1
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Yield:33543-78-1 76 %
Reaction Conditions:
Stage #1: 1H-imidazole;carbon dioxidewith potassium tert-butylate;caesium carbonate in 1,2-dimethoxyethane at 120; under 76.0051 Torr;Sealed tube;
Stage #2: ethyl iodide in N,N-dimethyl-formamide at 50;regioselective reaction;Time;Temperature;Solvent;Reagent/catalyst;
Steps:
Procedure for carboxylation reaction
General procedure: To 10 mL sealed Schlenk tube ventilated with CO2 added substrate (0.50 mmol), t-Bu0K (0.60 mmol), Cs2CO3(0.60 mmol) and DMF (3.0 mL). The mixture was stirred for 18 h at 120 °C under 0.10 MPa carbon dioxideatmosphere. After the mixture was cooled to 50 °C, Iodoethane (3.0 equiv.) was added to the mixture. and the reactionmixture was stirred at 50 °C for 2 h. at ambient temperature, the product was extracted with CH2Cl2 (5×5 mL) andwashed with saturated NaCl aqueous solution (5×5 mL). The organic phase was dried by Na2SO4, then concentratedby distillation and purified by column chromatography.
References:
Zhang, Chengyan;Chen, Yanjiao;Wang, Yaya;Peng, Xinhua [Synthesis,2022] Location in patent:supporting information
64-17-5
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163769-73-1
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33543-78-1
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865998-45-4
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33543-78-1
213 suppliers
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