ChemicalBook CAS DataBase List Ethyl 4-(bromomethyl)benzoate

Ethyl 4-(bromomethyl)benzoate synthesis

12synthesis methods

Product Name:Ethyl 4-(bromomethyl)benzoate
CAS Number:26496-94-6
Molecular formula:C10H11BrO2
Molecular Weight:243.1

64-17-5 Synthesis

64-17-5
727 suppliers
$10.00/50g

6232-88-8 Synthesis

6232-88-8
320 suppliers
$10.00/1g

26496-94-6
108 suppliers
$10.00/5g

Yield:26496-94-6 75%

Reaction Conditions:

with dmap;dicyclohexyl-carbodiimide in dichloromethane at 0; for 12 h;Inert atmosphere;

Steps:

Syntheses of compounds 6e-6j
General procedure: General Method H: To a solution of the acid (1.0 equiv.) in DCM, DCC (1.5 equiv.) was added and followed byalcohol (1.0 equiv.). Catalytic amount of DMAP was then added to the mixture. The reaction mixture was stirredovernight under N2. Water (5.0 mL) was added and the mixture was extracted with DCM. The organic phase waswashed with brine, dried over Na2SO4, filtered and concentrated. The residue was purified by silica gelchromatography (EtOA/hexane) to afford pure products.

References:

Liu, Hao;Chen, Li;Zhou, Fei;Zhang, Yun-Xiao;Xu, Ji;Xu, Meng;Bai, Su-Ping [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 14,p. 3089 - 3096] Location in patent:supporting information

FullText

94-08-6 Synthesis