ChemicalBook CAS DataBase List ETHYL 3-(2-FURYL)PROPIONATE

ETHYL 3-(2-FURYL)PROPIONATE synthesis

12synthesis methods

Product Name:ETHYL 3-(2-FURYL)PROPIONATE
CAS Number:10031-90-0
Molecular formula:C9H12O3
Molecular Weight:168.19

By direct esterification of the acid, which in turn is prepared by condensation of furfural with acetic anhydride and sodium acetate, followed by hydrogenation of the furacrylic acid

617-88-9
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$250.00/250 mg

105-39-5 Synthesis

105-39-5
406 suppliers
$10.00/5g

10031-90-0
67 suppliers
$30.19/5g

Yield: 89%

Reaction Conditions:

Stage #1:2-Chloromethylfuran with magnesium in diethyl ether at -5; for 1 h;
Stage #2:chloroacetic acid ethyl ester in diethyl ether at 20; for 6 h;

Steps:

1 Example 1; Preparation of condensation products; Preparation of a condensation product of 2-chloromethylfuran and ethyl chloroacetate.
Add 1.16 g to a 100 mL three-necked flask equipped with a reflux condenser and a constant pressure dropping funnel.The substrate was 2-chloromethylfuran, and 20 ml of diethyl ether as a solvent was added.3.6 g of magnesium was added in portions at -5 ° C, and a gas appeared, and the addition was completed.After 1 h of heat preservation reaction, a solution of 1.32 g of ethyl chloroacetate in 10 ml of diethyl ether was added dropwise, and the mixture was added to room temperature for 6 h.After the completion of the reaction, a saturated ammonium chloride solution was added, followed by extraction, liquid separation, and the organic layer was spin-dried to obtain a condensation product.Weighed, the yield was 89%.

References:

University of Science and Technology of China;Fu Yao;Li Xinglong;Xie Guangxia;Chen Shiyan;Kong Qingshan CN109503353, 2019, A Location in patent:Paragraph 0040-0044