ChemicalBook CAS DataBase List Ethyl 2-aminothiazole-5-carboxylate

Ethyl 2-aminothiazole-5-carboxylate synthesis

9synthesis methods

Product Name:Ethyl 2-aminothiazole-5-carboxylate
CAS Number:32955-21-8
Molecular formula:C6H8N2O2S
Molecular Weight:172.2

1001-26-9 Synthesis

1001-26-9
202 suppliers
$6.00/1g

57-13-6 Synthesis

57-13-6
718 suppliers
$5.00/5g

32955-21-8
377 suppliers
$7.00/1g

Yield:32955-21-8 95.7%

Reaction Conditions:

with potassium sulfide;copper in tetrahydrofuran;water at 55; for 1.5 h;Inert atmosphere;Temperature;

Steps:

1 Example 1
A method for the synthesis of an intermediate of dasatinib,The method comprises: under nitrogen protection,Ethyl 3-ethoxyacrylate (14.4 g, 100 mmol)And urea 12 g (200 mmol)And potassium sulfide 33. lg (300 mmol) of nano-copper powder 1.4 g (10%1 OOnm) under the catalytic 55 ° C contact reaction 1.5 hours,The solvent for the contact reaction was 100 ml of a 6: 1 by volume mixture of THF and H20,Cooled to room temperature,Poured into ice water,Dichloromethane extraction,The organic phase was concentrated,Washed,Then recrystallized from ethanol,Amino-thiazole-5-carboxylic acid ethyl ester of dasatinib as an intermediate, 16.5 g,The yield was 95.7%Purity 99.34%.

References:

Qingdao Chenda Biological Technology Co., Ltd.;Chen, Linghao CN106008393, 2016, A Location in patent:Paragraph 0034; 0035

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1001-26-9 Synthesis

1001-26-9
202 suppliers
$6.00/1g