Ethyl 2-(aminomethyl)nicotinate hydrochloride synthesis
- Product Name:Ethyl 2-(aminomethyl)nicotinate hydrochloride
- CAS Number:697739-11-0
- Molecular formula:C9H13ClN2O2
- Molecular Weight:216.67
75358-90-6
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Yield:697739-11-0 100%
Reaction Conditions:
with hydrogenchloride;hydrogen;palladium 10% on activated carbon in water; under 2585.81 Torr;
Steps:
35 Description 35: F3-ETHOXYCARBONYLPYRIDIN-2-YLLMETHANAMINIUM CHLORIDE
To a nitrogen flushed solution of Description 34 (14.27 g, 81 mmol) and conc. HC1 (15 ml) was added 10% Palladium on carbon (2 g), and the resulting mixture hydrogenated at 50 psi until HPLC and MS indicated complete conversion (approx 2 days). The catalyst was removed by filtration and the filtrate evaporated to give the title compound (17.55 g, 100%).
References:
WO2004/46133,2004,A1 Location in patent:Page 31-32
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