ETHYL 2 5-DIHYDROXYBENZOATE 97 synthesis
- Product Name:ETHYL 2 5-DIHYDROXYBENZOATE 97
- CAS Number:3943-91-7
- Molecular formula:C9H10O4
- Molecular Weight:182.17
490-79-9
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109-63-7
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3943-91-7
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Yield:3943-91-7 99%
Reaction Conditions:
at 120; for 4 h;
Steps:
Representative procedure (compound 1)
General procedure: In a 50 mL two-necked round-bottomed flask equipped with a magnetic stirring bar, a reflux condenser and a calcium chloride drying tube was placed nicotinic acid (1 g, 8.1 mmol) suspended in boron trifluoride etherate (10 mL). The reaction mixture was stirred and heated to 120 °C overnight during which the creamy reaction mixture changed into a brownish solution. Thin layer chromatography (hexane/ethyl acetate 3:1) revealed complete reaction. The cooled reaction mixture was diluted with water (25 mL) and extracted with ethyl acetate (3 x 10 mL). The combined organic extract was washed to the end of effervescence with a saturated solution of NaHCO3. The organic phase was dried over anhydrous Na2SO4 and concentrated in vacuo giving a crude yield of 1.11 g (92%).
References:
Jumbam, Ndze D.;Maganga, Yamkela;Masamba, Wayiza;Mbunye, Nomthandazo I.;Mgoqi, Esethu;Mtwa, Sphumusa [Bulletin of the Chemical Society of Ethiopia,2018,vol. 32,# 2,p. 387 - 392]
64-17-5
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490-79-9
509 suppliers
$5.00/100mg
3943-91-7
48 suppliers
$28.00/500mg
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77220-06-5
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140-88-5
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3943-91-7
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$28.00/500mg
64-67-5
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$14.00/5g
490-79-9
509 suppliers
$5.00/100mg
3943-91-7
48 suppliers
$28.00/500mg
89-57-6
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$5.00/50mg
3943-91-7
48 suppliers
$28.00/500mg