Erdosteine synthesis
- Product Name:Erdosteine
- CAS Number:84611-23-4
- Molecular formula:C8H11NO4S2
- Molecular Weight:249.31
3261-87-8
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$9.00/10g
10593-85-8
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84611-23-4
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$26.00/250mg
Yield:84611-23-4 82%
Reaction Conditions:
with sodium hydrogencarbonate in water; pH=6 - 9 at 10; for 0.5 h;
Steps:
5; 1
Dissolve 20 g of homocysteine thiolactone hydrochloride in water, add sodium bicarbonate to adjust the pH to 7-9, the temperature of the reaction solution is lower than 10°C, and then add the thioglycolic anhydride prepared in Example 1 (1.2 equivalents), keep the pH of the reaction solution at 6-7, react for half an hour, add hydrochloric acid to adjust the pH to 2-3, precipitate and filter to obtain crude erdosteine,According to the conventional purification method, 26.6 g of erdosteine was obtained (yield 82%)
References:
Wuhan Benjamin Pharmaceutical Co., Ltd.;Hu Kexiong;Wang Yuqin CN111995614, 2020, A Location in patent:Paragraph 0058-0061
68-11-1
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84611-22-3
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$65.00/500 mg
84611-23-4
240 suppliers
$26.00/250mg