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ChemicalBook CAS DataBase List DL-CARNITINE

DL-CARNITINE synthesis

6synthesis methods

Product Name:DL-CARNITINE
CAS Number:461-06-3
Molecular formula:C7H15NO3
Molecular Weight:161.2

[(±)-(4-amino-2-hydroxy-4-oxobutyl)trimethylammonium] chloride

5261-99-4
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461-06-3
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Yield:461-06-3 96.6%

Reaction Conditions:

with water;sodium hydroxide at 50; for 5 h;Product distribution / selectivity;

Steps:

IV.14
To the reaction completed solution in Example 10 (13.20 g; containing 2.45 g of Car-amide), 30% aqueous NaOH solution (2.68 g; 20.0 mmol) was added and the reaction was started at 50°C. Alter 5 hr, the conversion rate of Car-amide reached 100% and the reaction was completed. After neutralization of the system with aqueous HCl, water was removed in an evaporator under reduced pressure. Subsequently, 10 ml of ethanol was added thereto, followed by azeotropic distillation to remove the remaining water. This azeotropic distillation with ethanol was performed 3 times in the total. To the resultant white solid, 10 ml of ethanol was added again and agitated. Undissolved white solid (which is NaCl) was filtered by vacuum filtration. Quantitative determination of Car in the filtrate revealed that 1.94 g of Car (yield 96.6%) and 0.03 g of CB (1.5 wt % relative to Car) were produced.

References:

Mitsubishi Rayon Co. Ltd. EP2096103, 2009, A1 Location in patent:Page/Page column 24

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