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ChemicalBook CAS DataBase List Disuccinimidyl glutarate
79642-50-5

Disuccinimidyl glutarate synthesis

2synthesis methods
-

Yield:-

Reaction Conditions:

with 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in acetone at 25; for 24 h;

Steps:

Experimental
General procedure: NHS-Cn was prepared as described by Chen et al. (2011) with a small modification; end-bit binary acid (15 mmol each; C2, C3, C4, C5, C6, C8, C10, C14) and NHS (40 mmol) were dissolved in acetone (25 mL), and then EDC (30 mmol) was added to the solution. The clear mixture was gently stirred at 25°C for 24 h. After the acetone was removed by rotary evaporation under reduced pressure, the residue was washed several times with deionised water and then dried under vacuum at 50°C. The crosslinker thus prepared was characterised by the 1H NMR and FT-IR spectra.

References:

Zhuang, Chen;Tao, Fu-Rong;Cui, Yue-Zhi [Chemical Papers,2016,vol. 70,# 4,p. 505 - 514]

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