Diosmetin synthesis
- Product Name:Diosmetin
- CAS Number:520-34-3
- Molecular formula:C16H12O6
- Molecular Weight:300.26
520-33-2
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520-34-3
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Yield:520-34-3 90.5%
Reaction Conditions:
with pyridine;iodine at 90;
Steps:
3 Synthesis of compound 1c
Hesperetin (5.0 g, 15.8 mmol) was dissolved in 80 mL of dry pyridine, added with iodine (4.8 g, 15 mmol), reacted at 90 °C, TLC followed the reaction process, the starting point disappeared to stop the reaction, after cooling to room temperature, Slowly add ice water under vigorous stirring to separate out a brown-black solid, filter with suction, wash the filter cake with 3% dilute hydrochloric acid until there is no pyridine odor, then use saturated sodium thiosulfate to remove unreacted elemental iodine, and dry to obtain a yellow crude product, Recrystallization from absolute ethanol gave 4.5 g of yellow powder with a yield of 90.5%.
References:
CN113956224,2022,A Location in patent:Paragraph 0032-0034
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520-34-3
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520-33-2
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520-34-3
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520-34-3
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520-34-3
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