ChemicalBook CAS DataBase List DIISOBUTYL PHOSPHITE

DIISOBUTYL PHOSPHITE synthesis

8synthesis methods

Product Name:DIISOBUTYL PHOSPHITE
CAS Number:1189-24-8
Molecular formula:C8H19O3P
Molecular Weight:194.21

78-83-1 Synthesis

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762-04-9
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Yield: 85%

Reaction Conditions:

with sodium at 155 - 190;

Steps:

2. General Reaction Procedure for the Preparation of Dialkyl Phosphites¹
General procedure: Metallicsodium (0.2 g, 0.0087 mol) was dissolved in 0.3 mol of corresponding alcohol(22.2 g of butyl alcohol, 22.2 g of isobutyl alcohol,or 34.8 g of heptyl alcohol), then diethylphosphite was added (13.8 g, 0.1 mol). The mixture was heatedfor nearly 3 h in an oil bath with starting temperature 155 ^oC in a100-mL round-bottomed flask equipped with a 10-cm fractional distillation headuntil ethanol was completely distilled. The bath temperature was graduallyincreased during the reaction to 190 ^oC to achieve permanent removalof ethanol from the reaction mixture. Fractional distillation of the residualliquid in a short pathdistillation apparatus under reduced pressure afforded dialkyl phosphite ascolorless liquid. The physical constants of the prepared dialkyl phosphites arein agreement with the literature.⁸

References:

Salin, Alexey V.;Il'in, Anton V.;Shamsutdinova, Fanuza G.;Fatkhutdinov, Albert R.;Galkin, Vladimir I.;Islamov, Daut R.;Kataeva, Olga N. [Tetrahedron Letters,2015,vol. 56,# 45,p. 6282 - 6286] Location in patent:supporting information

78-83-1 Synthesis

78-83-1
781 suppliers
$14.00/5mL