Diethyl squarate synthesis
- Product Name:Diethyl squarate
- CAS Number:5231-87-8
- Molecular formula:C8H10O4
- Molecular Weight:170.16
122-51-0
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2892-51-5
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5231-87-8
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Yield:5231-87-8 97%
Reaction Conditions:
in ethanol at 80; for 48 h;
Steps:
2.2.8 Synthesis of 2-diethoxy-1-cyclobutene-3,4-dione
To a stirred solution of 3,4-dihydroxycyclobut-3-ene-1,2-dione (3.00g, 26.4mmol) in anhydrous ethanol (150mL) was added triethyl orthoformate (72.2mmol, 12.0mL) at room temperature. The mixture was heated to reflux at 80°C and left for 48h before being concentrated under reduced pressure. The crude yellow oil was purified by flash chromatography (DCM) to yield the title compound (3.57g, 97%) as an intensely yellow oil which was not purified further; 1H NMR (300MHz, CDCl3): δ 4.72 (m, 4H), 1.44 (t, J=87.9Hz, 6H). Data are in agreement with that previously reported [43].
References:
Ryan, Philip;Shi, Yun;von Itzstein, Mark;Rudrawar, Santosh [Bioorganic Chemistry,2021,vol. 110,art. no. 104738]
79-37-8
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2892-51-5
392 suppliers
$5.00/1g
5231-87-8
217 suppliers
$10.00/1g
64-17-5
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61699-62-5
127 suppliers
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5231-87-8
217 suppliers
$10.00/1g
64-17-5
725 suppliers
$10.00/50g
122-51-0
495 suppliers
$10.00/5ml
2892-51-5
392 suppliers
$5.00/1g
5231-87-8
217 suppliers
$10.00/1g