ChemicalBook CAS DataBase List DIETHYL GLUTAMATE

DIETHYL GLUTAMATE synthesis

7synthesis methods

Product Name:DIETHYL GLUTAMATE
CAS Number:55895-85-7
Molecular formula:C9H17NO4
Molecular Weight:203.24

64-17-5 Synthesis

64-17-5
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$10.00/50g

617-65-2 Synthesis

617-65-2
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$6.00/25g

55895-85-7
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inquiry

66183-71-9
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$17.00/5g

Yield:66183-71-9 50 %Chromat.

Reaction Conditions:

hydrogenchloride in water at 260; under 54005.4 Torr;

Steps:

1

A mixture of ethanol and glutamic acid was initially charged in a stirred vessel (A). The fraction of glutamic acid was 0.1% of the ethanol fraction. The mixture was conveyed continuously through the reactor (C) at a pressure of 72 bar by a suitable pump (B). The tubular reactor (C) was heated to a temperature of 260° C. by the heater (D). A carrier stream of pure ethanol from the reservoir (F) was heated to the same temperature using the preheater (G). At the mixing point (H), the carrier stream was mixed with the reactant stream (ratio 50/50) and fed to the reactor (C). The preheating temperature selected was so high that there was already reaction temperature at the mixing point, so that the temperature gradient in the reactor (C) was sufficiently small to prevent carbonization at the wall. The residence time in the tubular reactor (C) was 40 sec. With the aid of the control valve (E), the pressure was kept at the target value mentioned. At the outlet of the system, the reacted solution was introduced into 1 molar HCl. According to HPLC, 50% product yield (ethyl pyroglutamate) was obtained.

References:

US2005/192460,2005,A1 Location in patent:Page/Page column 3