Dicyclopropane methylamine synthesis
- Product Name:Dicyclopropane methylamine
- CAS Number:13375-29-6
- Molecular formula:C7H13N
- Molecular Weight:111.18
1453-52-7
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13375-29-6
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Yield: 85.8%
Reaction Conditions:
with nickel;sodium hydroxide in water at 70 - 80; under 15001.5 Torr; for 4 h;Inert atmosphere;Autoclave;Reagent/catalyst;Temperature;
Steps:
4 Preparation of bicyclopropylmethylamine by catalytic hydrogenation
In a 500 ml autoclave, 100 g of bicyclopropyl ketoxime, 6 g of Raney nickel, 350 ml of water and 10 g of sodium hydroxide were added.Then nitrogen was replaced three times, and hydrogen was introduced. Control reactor hydrogen pressure of 2Mpa, the temperature is 70-80 ,After 4 hours, the reaction was completed. Discharge, cooling, stirring, suction, remove Rennes nickel.And then extracted with dichloromethane 200ml three times, combined methylene chloride solution, distillation.Collect 100mmHg, 100-110 fractions, that is, product bicyclopropyl methylamine. A total of about 81 g of product was obtained in a yield of 85.8%.
References:
Chengdu Syns Medical Technology, Co.,LTD;Han, WeiHua;Huang, Song CN104672093, 2016, B Location in patent:Paragraph 0027-0028
1121-37-5
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13375-29-6
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$9.00/100mg
14300-33-5
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13375-29-6
128 suppliers
$9.00/100mg