DIBROMOACETOPHENONE synthesis

13synthesis methods

Product Name:DIBROMOACETOPHENONE
CAS Number:13665-04-8
Molecular formula:C8H6Br2O
Molecular Weight:277.94

2425-28-7 Synthesis

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Yield: 89%

Reaction Conditions:

with 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione in 1,2-dimethoxyethane;water at 80; for 4 h;

Steps:

Control experiments
DBH (143 mg, 0.5 mmol) and 2-bromo-1-phenylethanol (3) (50 mg, 0.25 mmol) were added into DME-water (1.35 mL : 0.3 mL) at rt. The resultant mixture was heated to 80 °C and stirred for 4 h. Then the mixture was quenched by saturated sodium bicarbonate (1 mL), extracted with ethyl acetate, washed by brine, and dried over Na₂SO₄ subsequently. After concentrated in vacuo, the crude product was purified by prepared thin layer chromatography to give dibromoketone 2a (62 mg, 89%).

References:

Wu, Ping;Xu, Senhan;Xu, Hao;Hu, Haiyan;Zhang, Wei [Tetrahedron Letters,2017,vol. 58,# 7,p. 618 - 621] Location in patent:supporting information