ChemicalBook CAS DataBase List Desonide

Desonide synthesis

7synthesis methods

Product Name:Desonide
CAS Number:638-94-8
Molecular formula:C24H32O6
Molecular Weight:416.51

13951-70-7 Synthesis

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

13951-70-7
336 suppliers
$28.00/1g

67-64-1
6 suppliers
$19.10/10ml

638-94-8
446 suppliers
$23.52/250MG

Yield:638-94-8 85%

Reaction Conditions:

with boron trifluoride in tetrahydrofuran;acetonitrile at -5 - 10;Inert atmosphere;

Steps:

3 preparation of Desonide

Under N2 protection,A mixture of 16α-hydroxyprednisolone (II-1) (5 g, 1.33 mmol)And 47% boron trifluoride tetrahydrofuran solution (0.6 g) were added to acetonitrile (50 ml)The temperature is maintained between -5 ° C and 0 ° C,Acetone (III-2) (1.2 g) was slowly added dropwise,After dripping, the temperature was maintained at 0 to 10 ° C,After 5-6 h reaction, the solid was filtered,The solid was rinsed with acetonitrile and dried to give desonide 4.7g,Yield 85%, purity greater than 99% (HPLC),

References:

CN103421075,2017,B Location in patent:Paragraph 0037-0039