desmethylazelastine synthesis
- Product Name:desmethylazelastine
- CAS Number:47491-38-3
- Molecular formula:C21H22ClN3O
- Molecular Weight:367.87
1878-66-6
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47491-38-3
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Yield:-
Steps:
Multi-step reaction with 4 steps
1.1: sodium acetate / 1-methyl-pyrrolidin-2-one / 48 h / 200 °C
2.1: hydrazine / ethanol / 15 h / 85 °C
2.2: 2 h / 2 °C
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3.58 h / -20 - 20 °C
4.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C
References:
GLAXO GROUP LIMITED WO2007/122156, 2007, A1
![1H-Azepine-1-carboxylic acid, 4-[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]hexahydro-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/955359-87-2.gif)
955359-87-2
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47491-38-3
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478832-21-2
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47491-38-3
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188975-88-4
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47491-38-3
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85-44-9
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47491-38-3
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