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ChemicalBook CAS DataBase List Creatinine
60-27-5

Creatinine synthesis

6synthesis methods
-

Yield:60-27-5 90%

Reaction Conditions:

with ammonium hydroxide in neat (no solvent) at 20; for 0.5 h;Green chemistry;

Steps:

General experimental procedure for synthesis of 2-imnohydantoin (2).

General experimental procedure for synthesis of 2-imnohydantoin (2). Methyl N-cyano-N-alkyl/arylaminoacetate 1 was treated with aqueous ammonia solution (30%, specific gravity = 0.89) at room temperature as per reaction time mentioned in Scheme 1. The precipitate of product formed was filtered and dried to get the 2-iminohydantoins 2.

References:

Kumar, Vinod;Rana, Hemlata;Kaushik, M. P. [Tetrahedron Letters,2012,vol. 53,# 47,p. 6423 - 6425,3]

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