CIS-OCTAHYDROPYRROLO[3,4-B]PYRIDINE synthesis
- Product Name:CIS-OCTAHYDROPYRROLO[3,4-B]PYRIDINE
- CAS Number:151213-40-0
- Molecular formula:C7H14N2
- Molecular Weight:126.2
![(S,S)-6-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE DIHYDROCHLORIDE](/CAS/GIF/151213-39-7.gif)
151213-39-7
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151213-40-0
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Yield:151213-40-0 95.5%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 100; under 38002.6 - 45603.1 Torr;
Steps:
1; 2
Dissolve 140 g of the reduction product in 500 ml of methanol, add 14 g of 10% palladium carbon, pressurize with hydrogen gas to 50-60 atmospheres, heat to 100 degrees and react until the reaction is over, cool, filter out the palladium carbon, and concentrate the remainder to remove the methanol. After rectification, 78 grams of (S,S)-2,8-diazabicyclo[4,3,0]nonane (compound shown in formula VI) was obtained, with a yield of 95.5% and a chiral purity of 99.5%.
References:
Xiamen Bensu Pharmaceutical Co., Ltd.;Shen Xin;Chen Yingjiang;Wang Dan;Zhan Huaxing CN111100125, 2020, A Location in patent:Paragraph 0072-0073; 0083-0084; 0085; 0090
![1H-Pyrrolo[3,4-b]pyridine, octahydro-1-[(1R)-1-phenylethyl]-6-(phenylmethyl)-, (4aS,7aS)-](/CAS/20200611/GIF/1430075-03-8.gif)
1430075-03-8
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151213-40-0
297 suppliers
$23.00/250mg
1430075-08-3
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151213-40-0
297 suppliers
$23.00/250mg