
CHELIDONINE synthesis
- Product Name:CHELIDONINE
- CAS Number:476-32-4
- Molecular formula:C20H19NO5
- Molecular Weight:353.37

249636-72-4
4 suppliers
inquiry

476-32-4
190 suppliers
$29.00/1mg
Yield:-
Steps:
Multi-step reaction with 10 steps
1.1: silver carbonate; palladium diacetate / benzene / 16 h / Reflux
2.1: (S)-(-)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; C53H50IrNO2P(1+)*BF4(1-); N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
2.2: 0.5 h / 20 °C
3.1: sodium tetrahydroborate; methanol / 0.5 h / 0 °C
4.1: potassium hydroxide / 2 h / 0 - 20 °C
5.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0.5 h / 0 - 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C
7.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 1 h / 70 °C / Inert atmosphere
8.1: N-Bromosuccinimide; water / tetrahydrofuran / 1.5 h / 20 °C
9.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / -78 °C
10.1: lithium aluminium tetrahydride / tetrahydrofuran; 1,4-dioxane / 17 h / Reflux
References:
Fyfe, James W. B.;Hutchings-Goetz, Luke S.;Snaddon, Thomas N.;Yang, Chao [Angewandte Chemie - International Edition,2020,vol. 59,# 40,p. 17556 - 17564][Angew. Chem.,2020,vol. 132,# 40,p. 17709 - 17717,9]
![1,3-Dioxolo[4,5-i][1,3]dioxolo[4,5]benz[1,2-c]oxireno[a]phenanthridine-12(13H)-carboxylic acid, 5b,5c,6a,11b-tetrahydro-, phenylmethyl ester, (5bR,5cR,6aS,11bS)-](/CAS/20210305/GIF/1032645-05-8.gif)
1032645-05-8
0 suppliers
inquiry

476-32-4
190 suppliers
$29.00/1mg