Carvedilol synthesis
- Product Name:Carvedilol
- CAS Number:72956-09-3
- Molecular formula:C24H26N2O4
- Molecular Weight:406.47
1836-62-0
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$6.00/10g
51997-51-4
317 suppliers
$7.00/5g
72956-09-3
576 suppliers
$19.00/1mg
Yield:72956-09-3 81%
Reaction Conditions:
in isopropyl alcohol for 5 h;Inert atmosphere;Reflux;
Steps:
4.1.4. General procedure (C) for the synthesis of 1-arylamino-3-aryloxypropan-2-ols
General procedure: Corresponding 2-(aryloxymethyl)oxiranes (5 mmol, 1 equiv) and amines (7.5 mmol, 1.5 equiv) were dissolved in 30 mL i-PrOH. The reaction was purged with argon 3 times and stirred at reflux for 5 h, andthen the mixture was cooled to room temperature and added AcOEt.After washing with brine 3 times, the organic layer was dried overanhydrous Na2SO4, filtered, and evaporated in vacuo. Purification ofthe crude residue by column chromatography on silica gel yielded target compounds.
References:
Chang, Qi;Long, Jing;Hu, Liqing;Chen, Zhuo;Li, Qianbin;Hu, Gaoyun [Bioorganic and Medicinal Chemistry,2020,vol. 28,# 9,art. no. 115404]
72955-94-3
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$177.00/10 mg
72956-09-3
576 suppliers
$19.00/1mg
![2-Oxazolidinone, 5-[(9H-carbazol-4-yloxy)methyl]-3-[2-(2-methoxyphenoxy)ethyl]-](/CAS/20210305/GIF/180987-80-8.gif)
180987-80-8
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72956-09-3
576 suppliers
$19.00/1mg
51997-51-4
317 suppliers
$7.00/5g
72956-09-3
576 suppliers
$19.00/1mg
1836-62-0
318 suppliers
$6.00/10g
51997-51-4
317 suppliers
$7.00/5g
918903-20-5
56 suppliers
$721.88/1MG
72956-09-3
576 suppliers
$19.00/1mg