ChemicalBook CAS DataBase List carbazol-3-ylamine

carbazol-3-ylamine synthesis

12synthesis methods

Product Name:carbazol-3-ylamine
CAS Number:6377-12-4
Molecular formula:C12H10N2
Molecular Weight:182.22

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Yield: 95%

Reaction Conditions:

with palladium 10% on activated carbon;hydrazine hydrate in ethanol at 80; for 24 h;Inert atmosphere;

Steps:

6.2 (2) Synthesis of Intermediate 9H-carbazol-3-amine
After 2.122g (0.01mol) 3-nitro-9H-carbazole were added to three 500ml flask, 450ml of absolute ethanol, a magnetic stirrer and argon gas, was heated to 80 deg.] C oil bath, was added 10% wt palladium on carbon 0.1 G, and hydrazine hydrate was gradually added dropwise 4ml, after the reaction was refluxed for 24h, the reaction solution was suction filtered and the filtrate was cold crystallization, the resulting cake was suction filtered and dried in vacuo 80 24h, to give the product 1.731g, 95% yield. This intermediate structure is as follows

References:

Hunan University of Technology;Tan, Jinghua;Xiong, Yufeng;Liu, Yiwu;Huang, Jie;Zhao, Shengqiu;He, Weilin;Zeng, Yi CN105622487, 2016, A Location in patent:Paragraph 0105; 0106; 0107

96187-18-7 Synthesis