Carbamimidothioic acid, propyl ester synthesis
- Product Name:Carbamimidothioic acid, propyl ester
- CAS Number:2986-21-2
- Molecular formula:C4H10N2S
- Molecular Weight:118.2
Yield:2986-21-2 96%
Reaction Conditions:
in ethanol; for 4 h;Reflux;
Steps:
1
258.3 g (2.1 moles) of 1-bromopropane, 152 g (2 moles) of thiourea and 400 ml of absolute ethanol were added to a 1000 ml three-necked flask equipped with a mechanical stirrer, reflux condenser and thermometer, and the system was heated with stirring And the mixture was allowed to react under reflux for 4 hours. The heating was stopped, the system was cooled to 15-25 ° C and 106 g (1 mole) of anhydrous sodium carbonate was added slowly at this temperature. After the addition of the anhydrous sodium carbonate was completed, stirring was continued for 30 minutes, and the stirring was stopped. Filtration gave 201 g of a white filter cake, predominantly sodium bromide. The filtrate was decompressed to recover the solvent and excess 1-bromopropane, and the residue was S-n-propylisothiourea in 254 g., Yield 96%.
References:
CN105777594,2016,A Location in patent:Paragraph 0015; 0017; 0019
