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ChemicalBook CAS DataBase List BOC-(R)-ALPHA-PROPYNYL-PROLINE
959578-39-3

BOC-(R)-ALPHA-PROPYNYL-PROLINE synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: acetyl chloride / 20 h / Reflux; Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere
3: water; sodium hydroxide / methanol / 3 h / 50 °C / Inert atmosphere

References:

Crick, Peter J.;Simpkins, Nigel S.;Highton, Adrian [Organic Letters,2011,vol. 13,# 24,p. 6472 - 6475]