ChemicalBook CAS DataBase List Beta-mangostin

Beta-mangostin synthesis

12synthesis methods

Product Name:Beta-mangostin
CAS Number:20931-37-7
Molecular formula:C25H28O6
Molecular Weight:424.49

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Yield: 70.3%

Reaction Conditions:

with sodium methylate in dimethyl sulfoxide for 4 h;Reflux;Inert atmosphere;

Steps:

5 Example 5; Preparation of β-mangostin:
The β-mangostin-OMe (VI) 50mg (0.114mmol) was dissolved in 3ml DMSO, was added CH 3 ONa92.3mg (1.71mmol), was slowly warmed to reflux under N 2, for 4 hours, cooled to room temperature, the reaction mixture poured into 20ml of water, made acid with 10% HCl, the precipitated solid was dark yellow, suction filtration, dried, purified by column chromatography (petroleum ether: ethyl acetate = 8) to give a yellow solid β-mangostin179mg, yield 70.3%.

References:

CHINA PHARMACEUTICAL UNIVERSITY;WANG, JINXIN;MIAO, GUANGQIANG;YANG, KAN;GU, QINLAN;CUI, BO;HUANG, ZHIPENG CN103864747, 2016, B Location in patent:Paragraph 0067-0069