Benzothiazole, 4-methoxy-2-methyl- (7CI,8CI,9CI) synthesis
- Product Name:Benzothiazole, 4-methoxy-2-methyl- (7CI,8CI,9CI)
- CAS Number:5304-19-8
- Molecular formula:C9H9NOS
- Molecular Weight:179.24
29277-46-1
7 suppliers
inquiry
5304-19-8
10 suppliers
inquiry
Yield:5304-19-8 25%
Reaction Conditions:
with potassium hydroxide;potassium hexacyanoferrate(III) in water at 100; for 4 h;
Steps:
156.2 Step 2
4-Methoxy-2-methylbenzo[d]thiazole (Compound 156-2)
Compound 156-1 (8.0 g, 44.19 mmol) was dissolved in water (480 mL).
Potassium hydroxide (11.38 g, 203.27 mmol) and potassium ferricyanide (33.40 g, 101.65 mmol) were added to the solution, and the mixture was stirred at 100°C for 4 hours.
The mixture was left to cool to room temperature and water was added to the mixture.
The organic layer was extracted with ethyl acetate, dried over anhydrous sodium sulfate, and concentrated under reduced pressure.
The residue was purified by silica gel column chromatography (hexane/ethyl acetate = 100/0 -> 80/20) to obtain compound 156-2 (2.0 g, 25%).
1H NMR (400 MHz, CDCl3, δ): 7.40 (dd, J = 8.0, 0.8 Hz, 1H), 7.29 (t, J = 8.0 Hz, 1H), 6.88 (dd, J = 8.0, 0.4 Hz, 1H), 4.03 (s, 3H), 2.84 (s, 3H).
References:
EP3712129,2020,A1 Location in patent:Paragraph 1231
93-26-5
110 suppliers
$25.00/5g
5304-19-8
10 suppliers
inquiry
90-04-0
392 suppliers
$5.00/5G
5304-19-8
10 suppliers
inquiry
446-61-7
130 suppliers
$10.00/100mg
5304-19-8
10 suppliers
inquiry
641-49-6
110 suppliers
inquiry
5304-19-8
10 suppliers
inquiry