Arbutin synthesis
- Product Name:Arbutin
- CAS Number:497-76-7
- Molecular formula:C12H16O7
- Molecular Weight:272.25
14698-56-7
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497-76-7
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Yield:497-76-7 90%
Reaction Conditions:
with ammonium chloride in water at 70; for 2 h;Concentration;
Steps:
1 Example 1
Tetraacetyl arbutin 44g (0.1mol) into the three-necked flask with stirring, was added 200ml of toluene, stirringDissolved, warmed to 60 ° C, 112 g (0.11 mol) of acetic anhydride was slowly added dropwise, and the addition was completed within half an hour. Stirring was continued for 1 hour, and the toluene was distilled off under reduced pressure to obtain pentacetyl arbutin solid. Then directly add 80g (0.15mol) of 10% ammonium chloride aqueous solution to the flask, raise the temperature to 70 ° C, stir for 2 hours, cool down to room temperature, precipitate crystals, filter and dry to obtain arbutin 24.5g, yield 90 %.
References:
CN107216359,2017,A Location in patent:Paragraph 0022; 0023; 0024; 0025; 0026; 0027
123-31-9
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2816-24-2
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497-76-7
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492-61-5
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7400-08-0
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497-76-7
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56401-20-8
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$31.19/10mg
123-31-9
839 suppliers
$13.00/25g
497-76-7
734 suppliers
$5.00/5g