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ChemicalBook CAS DataBase List (±)-amino(2-fluorophenyl)acetic acid
84145-28-8

(±)-amino(2-fluorophenyl)acetic acid synthesis

8synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; acetone / 17 h / 0 - 20 °C / Inert atmosphere
2: acetic acid; 9-benzyl-9-norazaadamantane N-oxyl; sodium nitrite / water; acetonitrile / 18 h / 20 °C
3: (S)-2-amino-(2-chlorophenyl)ethanoic acid / water; acetonitrile / 36 h / 50 °C / Reflux; Inert atmosphere

References:

Inada, Haruki;Shibuya, Masatoshi;Yamamoto, Yoshihiko [Journal of Organic Chemistry,2020,vol. 85,# 17,p. 11047 - 11059]