ALPHA-KETOGLUTARIC ACID MONOSODIUM SALT synthesis
- Product Name:ALPHA-KETOGLUTARIC ACID MONOSODIUM SALT
- CAS Number:22202-68-2
- Molecular formula:C5H5NaO5
- Molecular Weight:168.08
328-50-7
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22202-68-2
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Yield:-
Reaction Conditions:
with sodium hydride in tetrahydrofuranProduct distribution / selectivity;
Steps:
5; 6; 7; 8; 9; 10; 11; 12
2-oxo-pentanedioic acid was dissolved in THF under nitrogen. To this solution was addedone equivalent of NaH. The resulting sodium salt of the a-keto acid was then treateddropwise with one equivalent of (1R, 2R, 4S)-2-bromo-1-isopropyl-4-methyl-cyclohexaneover a period of 100 hours. See, for example, Domagala, 1980.
References:
CANCER RESEARCH TECHNOLOGY LIMITED WO2006/16143, 2006, A1 Location in patent:Page/Page column 60; 61; 62; 63
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1000210-73-0
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529-96-4
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22202-68-2
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142-47-2
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22202-68-2
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