ChemicalBook CAS DataBase List N-Allylthiourea

N-Allylthiourea synthesis

6synthesis methods

Product Name:N-Allylthiourea
CAS Number:109-57-9
Molecular formula:C4H8N2S
Molecular Weight:116.18

In the presence of potassium iodide, in ethanol solution, chloropropene is reacted with sodium thiocyanide to form allyl isothiocyanate, which is then ammoniated in ammonium hydroxide solution, concentrated, cooled and crystallized, filtered, washed, and recrystallized in ethanol or water to produce Allylthiourea.

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103-81-1 Synthesis

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Yield:109-57-9 436.16 g

Reaction Conditions:

in water at 60; for 1.16667 h;Temperature;

Steps:

3 Example 3

Add 5L of 16% sodium chloride solution to the reaction vessel, 4mol3-methylisothiocyanate benzene, raise the temperature of the solution to 65 ° C, add 6mol of acrylamide and 6L of 20% acetone solution, reflux for 120min, let stand layer, remove the oil layer, wash with potassium bromide solution 7 times, obtained isopropyl thiocyanate, dehydrating agent dehydration, filtration, filtrate distillation under reduced pressure of 30 kPa, collecting fractions at 86 ° C to obtain propylene thiocyanate;Add propylene thiocyanate to 6 mol of phenylacetamide, add 2 L of aqueous solution, raise the temperature of the solution to 60 ° C, react for 70 min, lower the temperature of the solution to 15 ° C, precipitate crystals, filter, mass fraction of 80% toluene solution, mass fraction It was washed with 90% methyl ethyl ketone solution and dehydrated with anhydrous potassium carbonate dehydrating agent to obtain 436.16 g of the finished propylene thiourea with a yield of 94%.

References:

CN108264471,2018,A Location in patent:Paragraph 0011; 0013; 0014; 0015

57-06-7 Synthesis