AKOS B033532 synthesis
- Product Name:AKOS B033532
- CAS Number:93246-54-9
- Molecular formula:C10H13FN2
- Molecular Weight:180.22
385380-74-5
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$19.00/1g
93246-54-9
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$75.00/1g
Yield:93246-54-9 88%
Reaction Conditions:
with hydrogen;palladium in methanol;dichloromethane at 20;
Steps:
21.2 [00339] Step 2) 3-fluoro-4-(pyrrolidin-1-yl)aniline
To a solution of 1-(2-fluoro-4-nitrophenyl) pyrrolidine (1.60 g, 7.62 mmol) in mixed solvents of CH2CI2 (20 mL) and MeOH (20 mL) was added catalyst Pd/C (0.16 g). The reaction was stirred at rt under 112 overnight, and filtered. The filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE / EtOAc (V / V) = 5: 1) to give the title compound as a white solid (1.20 g, 88%).
References:
WO2014/12360,2014,A1 Location in patent:Paragraph 00339
369-34-6
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93246-54-9
27 suppliers
$75.00/1g