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ChemicalBook CAS DataBase List Afatinib impurity 41
69169-63-7

Afatinib impurity 41 synthesis

3synthesis methods
2-Butenoic acid, 4-[(ethoxycarbonyl)methylamino]-, ethyl ester, (E)- (9CI)

100241-84-7
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Yield:69169-63-7 35%

Reaction Conditions:

with sulfuric acid at 130; for 1 h;

References:

Falch;Krogsgaard-Larsen;Jacobsen;et al. [European Journal of Medicinal Chemistry,1985,vol. 20,# 5,p. 447 - 453]

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